NEUTROPHIL-LYMPHOCYTE RATIO AND HIGH SENSITIVITY C-REACTIVE PROTEIN AS ISCHEMIC STROKE OUTCOME PREDICTOR
| Main Authors: | Putri, Tissi Liskawini, Ganie, Ratna Akbari, Rambe, Aldy S. |
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| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
PERHIMPUNAN DOKTER SPESIALIS PATOLOGI KLINIK INDONESIA
, 2017
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| Subjects: | |
| Online Access: |
http://www.indonesianjournalofclinicalpathology.or.id/index.php/patologi/article/view/787 http://www.indonesianjournalofclinicalpathology.or.id/index.php/patologi/article/view/787/544 |
Daftar Isi:
- Inflammation process is the pathogeneses of the acute ischemic stroke, which involves the accumulation of inflammatorymediators and leukocyte infiltration. The neutrophil-lymphocyte ratio (NLR) in some studies can be used to predict the outcome ofan acute ischemic stroke and is easy to carry out. The high sensitivity C-reactive protein (hs-CRP) is an acute phase reactant whichlevels increase in existence of ischemic stroke, and therefore is useful as the predictor marker of the disease. The aim of this study isto know the difference value of RNL with hs-CRP in predicting the outcome of patients with acute ischemic stroke by determination.The analysis was carried observationaly with cohort prospective design. The outcome was then measured by modified Rankin Scale(mRS) (1-2 = good; 3-6 = poor) and Barthel Index (BI) (0-20 = total dependence; 21-60 = severe; 61-90 = moderate; 91-99 =mild and 100 = normal). Of the 43 samples, there were 24 males (55.8%) and 19 females (44.2%) with the mean age about 57.12±9.8years. There was positive, moderate and significant correlation between RNL with mRS and BI outcome of the acute ischemic strokepatients (r=0.585; p=0.001 and r=0.564; p=0.001). There was positive, strong and significant correlation between hs-CRP withmRS outcome (r=0.614; p=0.001); and there was positive, very strong and significant correlation between hs-CRP with BI outcomeof acute ischemic stroke patients (r=0.881; p=0.001). By comparing its accuracy, it was found that RNL is about 86% and 88% andhs-CRP (p=0.6554).There was no significant difference between the value of RNL with hs-CRP as the outcome predictor of acuteischemic stroke patients