ANALYSIS OF DENGUE SPECIFIC IMMUNE RESPONSE BASED ON SEROTYPE, TYPE AND SEVERITY OF DENGUE INFECTION
| Main Authors: | ., Irmayanti, Nurulita, Asvin, Sennang, Nurhayana |
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| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
PERHIMPUNAN DOKTER SPESIALIS PATOLOGI KLINIK INDONESIA
, 2017
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| Subjects: | |
| Online Access: |
http://www.indonesianjournalofclinicalpathology.or.id/index.php/patologi/article/view/786 http://www.indonesianjournalofclinicalpathology.or.id/index.php/patologi/article/view/786/543 |
Daftar Isi:
- Dengue infection causes a clinical severity from DF to DHF/DSS. Dengue specific immune response such as anti-dengue IgMand IgG is still controversial for the DHF pathogenesis besides virus virulence and type of infection. The study aim was to analyzedengue specific immune response to serotype, type and severity of dengue infection in Surabaya. Subjects were dengue infectionpatients hospitalized in the Tropical Infectious Disease Ward, Dr. Soetomo Hospital with positive results for NS1(SD Bioline DengueDuo) and/or PCR (Simplexa Dengue). Examination of quantitative IgM and IgG was performed by Panbio Dengue Duo IgM and IgGCapture ELISA. This study was done in March–August 2016 and comprised 61 patients with positive results for NSI and/or PCR.Serotype identification was dominated by DEN-3, but DEN-1 seems to be more virulent as all patients manifested as secondaryinfection and DHF. Primary infection consisted of 19 (31.1%) and secondary infection of 42(68.9%) patients. Clinical manifestationwere DF 10 (16.4%), DHF 47 (77%) and DSS 4 (6.56%). Mean index value of anti-dengue IgM and IgG in DEN-1 was (5.140 and5.774), DEN-2 (2.971 and 2.222), DEN-3 (1.863 and 2.792); primary infection (1.478 and 0.746), secondary infection (4.028 and4.864) and severity group of DF (1.170 and 1.492), DHF I (3.370 and 3.651), DHF II (3.924 and 4.439) and DHF III (4.164 and 4.243).In conclusion, dengue specific immune response was significantly higher in DEN-1 serotype infection group, secondary infectiongroup and DHF/DSS group.