CORRELATION BETWEEN NT-PROBNP AND LEFT VENTRICULAR EJECTION FRACTION BY ECHOCARDIOGRAPHY IN HEART FAILURE PATIENTS
| Main Authors: | S, Mutiara D, Anniwati, Leonita, Aminuddin, M. |
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| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
PERHIMPUNAN DOKTER SPESIALIS PATOLOGI KLINIK INDONESIA
, 2017
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| Subjects: | |
| Online Access: |
http://www.indonesianjournalofclinicalpathology.or.id/index.php/patologi/article/view/698 http://www.indonesianjournalofclinicalpathology.or.id/index.php/patologi/article/view/698/463 |
Daftar Isi:
- Biological marker NH2-terminal fragment of pro-Brain Natriuretic Peptide (NT-proBNP) is useful for early diagnosis, to role outthe clinical symptoms originating from outside the heart, monitoring treatment and predicting prognosis in heart failure patients.NT-proBNP eaxamination can be done automatically, so the results are not subjective. Echocardiography is the examination commonlyused to help diagnosing heart failure. However, echocardiography is not always available in all hospitals, especially small hospitalsin the rural areas and requires expertise in conducting examination and the results are subjective. One of the parameters assessedby echocardiography is the left ventricular ejection fraction (LVEF). The study design was quasi-experimental with pre-testand post-test approach only without control. Samples consisted of 41 subjects collected from February to April 2015 from the Correlation Between NT-Probnp and Left Ventricular Ejection Fraction - Mutiara, et al. 115Cardiology Unit, Dr. Soetomo Hospital, Surabaya. NT-pro BNP was examined using a solid-phase two-site chemiluminescentimmunometric assay as the principle. The results were statistically analyzed using Spearman’s correlation test, two sample paired ttest, Kruskal Wallis and Mann Whitney test. NT-proBNP levels before and after therapy in heart failure patients were each between1,296–3,474 pg/mL, mean 10,422.49 pg /mL (SD 8,608.05) and 997–3,401 pg/mL, mean 8,899.41 pg/mL (SD 8,489.46). The range ofthe percentage of LVEF before and after therapy in heart failure patients was etween 20–62%, mean 35.61% (SD 10.00) and 22–71%,mean 41.49% (SD 10.96). Significant differences in mean levels of NT-proBNP and LVEF before and after therapy in heart failurepatients with each value of p=0.001 were found. A significant negative correlation between levels of NT-proBNP with LVEF in heartfailure patients before and after therapy with the values of p=0.001, r=-0.81 and p=0.001, r=-0. 80, respectively was also shown.A significant negative correlation between the levels of NT-proBNP with LVEF in heart failure patients before and after therapy wasfound. Based on these conditions, examination of biological markers NT-proBNP can be suggested to be used as an alternative toechocardiography parameters for heart failure.