NILAI DIAGNOSTIK UJI TROPONIN I KUANTITATIF METODE IMMUNOKROMATOGRAFI
| Main Authors: | Fatonah, Siti, Widijanti, Anik, Hernowati, Tinny Endang |
|---|---|
| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
PERHIMPUNAN DOKTER SPESIALIS PATOLOGI KLINIK INDONESIA
, 2017
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| Subjects: | |
| Online Access: |
http://www.indonesianjournalofclinicalpathology.or.id/index.php/patologi/article/view/609 http://www.indonesianjournalofclinicalpathology.or.id/index.php/patologi/article/view/609/352 |
Daftar Isi:
- Cardiac troponins are the most sensitive and specific biochemical markers of myocardial damage but there is no standardization of WHO for cardiac troponin I, resulting in a variability for diagnostic value. It is necessary to determine diagnostic value for a new kit of troponin I. To evaluate a new quantitative immunochromatography assay for troponin I at a various cut off level. A cross sectional study was conducted in 64 patients with acute myocardial infarction (AMI) and 55 non-AMI as control from February to September 2007. The level of cardiac troponin I (cTnI) was measured and determined it diagnostic value at a various cut off level. The sensitivity, specificity, PPV and NPV of this assay were 91%, 91%, 92% and 89% at cut off level of 1,0 ng/ml (according to the kit), respectively. The cut off of cTnI were divided into five levels: 0.8, 1.0, 1.2, 1.5, and 2.0 with the area under curve were 0.923, 0.908, 0.912, and 0.897, respectively. The sensitivity were 94%, 91%, 86%, 81% and 72%, respectively, the specificity were 91%, 91%, 96%, 98% and 98%, respectively. This rapid diagnostic test is sensitive and specific to diagnose an acute coronary syndromes.