MALDI-TOF DAN SELDI-TOF MASS SPECTROMETRY DENGAN THROUGHPUT TINGGI UNTUK ANALISIS PROTEOMIK PROFIL PROTEIN DARI PETANDA BIOLOGIS
| Main Authors: | Andayaningsih, Trinovia, P., Siti Muchayat |
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| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
PERHIMPUNAN DOKTER SPESIALIS PATOLOGI KLINIK INDONESIA
, 2016
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| Subjects: | |
| Online Access: |
http://www.indonesianjournalofclinicalpathology.or.id/index.php/patologi/article/view/515 http://www.indonesianjournalofclinicalpathology.or.id/index.php/patologi/article/view/515/260 |
Daftar Isi:
- In recent years, proteomic approach has been widely used for diagnosing the diseases and matrix assisted laser desorption / ionization- time of the flight (MALDI-TOF) mass spectrometry and its modification, surface enhanced laser desorption /ionization-time of flight (SELDI-TOF) mass spectrometry have became very promising diagnostic tools. High throughputs and relative simplicity of these technologies attracted the researchers to know the biomarkers of specific diseases by analyzing specimens of serum/plasma and other body fluids. Analyzing plasma specimens by MALDI/SELDI TOF mass spectrometry provides new information especially about small protein and peptides in high abundance. Protein profilings, resulting by these technologies provide higher sensitivity and specificity values than current biomarkers. Knowing how these principle tools work and its promising application to early detection of specific diseases is the aim of writing this paper.