INTERLEUKIN-4 DAN INTERFERON GAMMA DI NEFRITIS LUPUS: HUBUNGAN AKTIVITAS PENYAKIT SERTA KEKAMBUHAN
| Main Authors: | Achamar, Torajasa, Farida, Dany, Susianti, Hani, Handono, Kusworini, Rastini, Ati, I, R., A.S, I Putu, Gunawan, Atma |
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| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
PERHIMPUNAN DOKTER SPESIALIS PATOLOGI KLINIK INDONESIA
, 2016
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| Subjects: | |
| Online Access: |
http://www.indonesianjournalofclinicalpathology.or.id/index.php/patologi/article/view/506 http://www.indonesianjournalofclinicalpathology.or.id/index.php/patologi/article/view/506/251 |
Daftar Isi:
- Sampling for urinalysis to see the activity and the degree of recurrence of Lupus Nephritis (LN) is very difficult. New biomarkers that are more simple, sensitive, specific and non-invasive in assessing the activity of the LN need to be investigated. Interleukin-4 (IL-4) and interferon gamma (IFN-γ) were implicated to LN process. Urine samples from 17 LN patients were taken every month for 6 (six) months to examine the level of uIL-4, uIFN-γ, activity and recurrence of LN. Significant differences were observed in the uIFN-γ levels between the active and inactive LN groups (p=0.012), but not in uIL-4 levels (p=0.187). Correlations between each biomarker and renal domain score were weak (r=0.201, p=0.042 for uIL-4; r=0.268, p=0.006 for uIFN-γ). Significant differences were also found in the uIL-4 and uIFN-γ levels against LN recurrence (p=0.033; p=0.017). The best cut off values to assess recurrences and activity of LN were 8.17 pg/mL for uIL-4 showed a sensitivity of 74%, specificity 71%, NPV 90%, PPV 42% to assess recurrences and to assess activity of LN showed sensitivity 46%, specificity 75%, NPV 48%, PPV 78%. The cut off 18.58 pg/mL for uIFN-γ to predict recurrent and assess the activity of LN showed sensitivity 68%%, specificity 70%, NPV 88%, PPV 40% to predict the recurrent and to assess the activity of LN showed sensitivity 57%, specificity 64%, NPV 49%, PPV 73%. Based on the research, uIL-4 and uIFN-γ are not good enough to predict recurrence and activity of LN