RUSIP SEHUBUNGAN PROFIL LIPID DALAM KEADAAN HIPERKOLESTEROLEMIA
| Main Authors: | KS, Indranila, MD, Satrianugraha |
|---|---|
| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
PERHIMPUNAN DOKTER SPESIALIS PATOLOGI KLINIK INDONESIA
, 2016
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| Subjects: | |
| Online Access: |
http://www.indonesianjournalofclinicalpathology.or.id/index.php/patologi/article/view/459 http://www.indonesianjournalofclinicalpathology.or.id/index.php/patologi/article/view/459/204 |
Daftar Isi:
- Rusip is a fermented fish product made from anchovies. Several lactic acid bacteria have been identified in rusip fermentation. Lactic acid bacteria are known to be able to reduce serum cholesterol. The aim of the research was to know the lipid profile changes due to administration of rusip in hypercholesterolemia rats. The research was done by using Pre and Post Randomized Controlled Group Design. The research subjects consisted of twenty-eight Sprague Dawley strain white male rats aged 20 weeks with normal body weight, who were given a high-fat high-cholesterol diet, then divided into four (4) groups: control group, without Rusip administration; P1, P2 and P3 who received 2.55; 5.10 and 7.65 mg Rusip/g body weight. After 14 days treatment, blood samples were taken to determine the lipid profile using enzymatic methods. ANOVA or alternative test, was used to test the difference between the groups at the 95% confidence level. Based on the research, the administration of Rusip in the treatment group caused significant changes in the lipid profiles of hypercholesterolemia rats (p<0.05). The total cholesterol, triglycerides and LDL cholesterol levels decreased significantly in all three treatment doses (p<0.05). The HDL cholesterol increased significantly in all three treatment doses (p<0.05). The highest change in lipid profile results was obtained in the treatment of P3 to all variables. In this study, it was found that administration of Rusip could improve the state of blood lipid profiles of hypercholesterolemia rats. Whereas, the highest changes were obtained in treatment with P3