ANALISIS POLA HUMAN LEKOCYTE ANTIGEN (HLA) KELAS I PADA PENDERITA DEMAM BERDARAH DENGUE POPULASI INDONESIA DI JAWA TIMUR
| Main Authors: | Judajana, F. M., Budiono, Paulus, Nuraini, Indah |
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| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
PERHIMPUNAN DOKTER SPESIALIS PATOLOGI KLINIK INDONESIA
, 2016
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| Subjects: | |
| Online Access: |
http://www.indonesianjournalofclinicalpathology.or.id/index.php/patologi/article/view/363 http://www.indonesianjournalofclinicalpathology.or.id/index.php/patologi/article/view/363/112 |
Daftar Isi:
- The incidence of Dengue Haemorrhagic Fever (DHF) is obvious rapidly increasing and it may have existed previously, and specific factors precipitating of the diseases can be identified in Indonesia population. These include environmental changes, demographic factors, host immunity, micro organism variant and drug resistance suggesting that infection will continue to emerge, probably increase and emphasizes the urgent need for effective surveillance. The Immunology approach of Dengue Haemorrhagic Fever as emerging diseases has been advanced on two major fronts. First, the elucidation of the basic mechanisms associated antigen recognition, elimination, rejection and immunological protection from recurrence. Secondly, to solve the clinical problem (diagnostic, therapeutic and prevention) the application of the knowledge of immunological memory to diseases is used as a tool. Over expressed emerging pathogens such as molecularly defined mutated antigen; this antigen as a target of specific immune reaction and has been encountered as a danger signal. The current studies have shown that few immune competent cells (activated T cells and B cells) are exposed to antigen. The immune consequence of infectious tissue induced Major Histocompatibility Complex (MHC)/Human Leukocyte Antigen (HLA) molecules expression on antigen presenting cell and have also shown, that an immunological reaction occurs in all organs in response to a number of diseases. However, most infectious diseases express MHC/HLA class II molecules, in order to recognize the new mutated antigen and also express the MHC/HLA class I molecules in order to eliminate those antigen. Progress in the genetic dissection of infectious diseases will also come from the complementary analysis of the various biological and clinical phenotypes associated with a given infectious agent, strongly suggesting that host factors play an important role in susceptibility or resistance to infection. In order to know the regulation process between different types of pathogen and the host immune system, as well as the regulation factor of the cross talk between the different components of the immune response in human as the host, it is important to get an understanding of the immune genetic system. This research work is aimed at the locating and identifying the HLA class I which encode the protein as immune-component to be involved in the pathogenesis of DHF as a viral infection base on the examination on 20 DHF patients and have already examined the HLA-A, -B as HLA class I with the DNA typing-PCR. The results analysis with Chi square with Yatesâs Correction and the relative risk (Wolf rule) is HLA-A*11,-A*24 and HLA-B*15,-B*18 has specific association with DHF on Indonesia population in East Java. The evidence of the influence of the immune genetics marker to the DHF is provided by the following observations: (1) the level of infection often differs greatly among infected subjects, (2) some infected subjects do not develop clinical disease, (3) the clinical manifestations of disease severity, time to onset, duration of disease etc, may differ greatly among symptomatic patients. This finding opens the path to develop effective means of immunotherapy and improved the diagnosis for lesions, in order to apply the current strategies for the developing of immunodiagnostic, immunotherapy-based treatment through an infected target cell or developed new effective vaccines.