ACETOSAL, BUAH MENGKUDU (MORINDA CITRIFOLIA L.) DAN WAKTU PERDARAHAN
| Main Authors: | Sutirta Yasa, I Wayan Putu, Astuti, Ketut Widyani, Aman, I Gusti Made |
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| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
PERHIMPUNAN DOKTER SPESIALIS PATOLOGI KLINIK INDONESIA
, 2016
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| Subjects: | |
| Online Access: |
http://www.indonesianjournalofclinicalpathology.or.id/index.php/patologi/article/view/361 http://www.indonesianjournalofclinicalpathology.or.id/index.php/patologi/article/view/361/110 |
Daftar Isi:
- Research regardless the effect of noni fruit for increasing bleeding time have already been carried out widely. The similar activity of noni fruit extract and acetosal can be concerned that the fruit extract has a potential activity for prolonged bleeding time. This study aims to know the present of prolonged of bleeding time as a results of intake of combination of noni fruit extract with acetosal on mice. This research was carried out at Unit Binatang Percobaan, Departemen Farmakologi Universitas Udayana. This is an experimental study with pre and post-test control group design. Subject was compromised of 3 groups of mice and each group contain of 7 mice. The first group was treated with a dose of 40 mg/kg bw acetosal, the second group treated with a dose of 100 mg/kg bw ethanol noni fruit extract, and the third group treated with combination of 40 mg/kg bw acetosal and 100 mg/kg bw ethanol extract of noni fruit. All groups were fed once per day for a week. Bleeding time was determined on the basis of tail bleeding method. This study results that the first group experience bleeding time increased from 61.42±9.43 second to 160.71±19.77 second. Increase bleeding time of the second group is from 59.14±7.12 to 138.14±59.91 second. For the third group, the bleeding time increases from 65.00±7.91 to 213.00±20.92 second. One Way ANOVA analysis indicates that there is a significant different among these three groups after treatment p = 0.006 (p<0.05). Bleeding time of the third group which was treated with combination of noni fruit and acetosal results in the highest increase compare to the other two groups. In conclusions, combination of noni fruit and acetosal treatment results in increase of bleeding time on mice.