ANALGESIC EFFECT OF ETHANOL EXTRACT OF LONG PEPPER (Piper retrofractum Vahl) ON MICE Swiss-Webster STRAIN
| Main Authors: | Evacusiany, Endang, Santosa, Slamet, Irwan, Maike |
|---|---|
| Format: | application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Jurnal Medika Planta
, 2013
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| Subjects: | |
| Online Access: |
http://majour.maranatha.edu/index.php/jmp/article/view/933 |
Daftar Isi:
- Introduction: Pain is a symptom that most people often complained about, which drive people to look for therapy. Some of analgesic drugs have many side effects which harming, for that need to looked for more safe alternative from nature. One of the therapies that have been used to alleviate the pain is herbal medicines,such as Piper retrofractum Vahl (Long Pepper). The objective of this research is to discover the analgesic effect of the ethanol extract of Long pepper. Methods: the research was a true prospective experimental study with Complete Randomize Trial Design that has comparative characteristic. The trial of analgesic effect was accomplished with thermal method as a pain inducement. The female mice Swiss Webster strain with ± 25 grams of weight were devided into five groups (n=5).The 1st, 2nd, 3rd groups were given The Ethanol Extract of Long Pepper (EECJ) with the dose of 0.75 g/KgBW, 1.5 g/KgBW, and 3 g/KgBW, 4th group was given CMC, and 5th group was given asetosal 0.42 g/KgBW. The data measured was the reaction time of the first pain response, such as lift or lick the forefoot, or jump, after the mice had been put against the hot plate.Data is analyzed using one way ANOVA, then followed by Tukey HSD mean different test, α=0.05. Results: the reaction time of group EECJ dose 0.75 g/KgBW, 1.5 g Kg/BW and 3 g/KgBW were significantly different if it was compared to control group with p of 0.000 respectively. Conclusion: The Ethanol Extract of Long Pepper has an analgesic effect on mice.