ANTIINFLAMMATORY EFFECT OF DANDELION INTO ATOPIC DERMATITIS MODELS USING MICE
| Main Authors: | Jasaputra, Diana Krisanti, Liana, Laella K., Sujatno, Muchtan, Soen, Mary |
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| Format: | application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Jurnal Medika Planta
, 2013
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| Subjects: | |
| Online Access: |
http://majour.maranatha.edu/index.php/jmp/article/view/932 |
Daftar Isi:
- Introduction: Atopic dermatitis is an inflammation of the skin based on hypersensitivity type I reaction. Medication for atopic dermatiis can be done in conventional or inconventional ways and dandelion (Taraxacum officinale Weber et Wiggers) is one of them. Objective: to determine antiinflammatory effect of dandelion’s aqueous and ethanol extract in reducing the inflammation area and the number of inflammatory cells on mice’s skin tissue with atopic dermatitis induced by ovalbumin. Methods: The characteristic of this research was prospective experimental laboratory, using mice, injected with 0.2 ml ovalbumin 10% intracutaneously, on the first, seventh, and twenty-first days. The mice were given dandelion’s aqueous and ethanol extract with dose 1: 0.0078g/ mice 20g; dose 2: 0.0195g/ mice 20g; dose 3: 0.039g/ mice 20g; dose 4: 0.078 g/ mice 20g perorally. Results: The results show that dandelion’s aqueous extract with dose 4 (6.640mm2) and ethanol extract with dose 2 (5.013mm2) were the most effective doses in reducing the inflammation area (p<0,05). The summary result of the number of inflammation cells shows statistically significant on giving the dandelion’s ethanol extract dose 1 and 2 compared with the positive control (p<0,05). The effectivity of ethanol extract equal to the aqueous extract in reducing the inflammation coverage area and the number of inflammation cells. Conclusion: both dandelion’s aqueous and ethanol extract are effective in reducing the inflammation coverage area, ethanol extract effective to reduce the number of inflammation cells. Both dandelion’s aqueous and ethanol extract are equally effective.