LD-50 and Delayed Toxicity Study of the Ethanol Extract of Nothopanax Scutellarium Merr. Leave
| Main Authors: | Rustam, Erlina; Bagian Farmakologi dan Terapeutik Fakultas Kedokteran Universitas Andalas, Masri, Machdawaty; Bagian Kimia Fakultas Kedoktearn Universitas Andalas, Arifin, Helmi; Bagian Farmakologi dan Farmasi Klinik Fakultas Farmasi Universitas Andalas |
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| Format: | application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Jurnal Medika Planta
, 2013
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| Subjects: | |
| Online Access: |
http://majour.maranatha.edu/index.php/jmp/article/view/880 |
Daftar Isi:
- Introduction: To ensure safety of using herbs in treatment needs to be done a series of toxicity tests include acute toxicity, subacute and chronic.Objective: to achieve these things already done research on acute toxicity study of plant extract Nothopanax scutellarium. Merr. on male mice.Methods: Parameter measured were LD50, the body weight, water intake, urin output, the relative weight of the liver, heart and kidney.Results: The toxicity evaluation by oral administration of etanolic extract of Nothopanax scutellarium. Merr.'s leaves showed that the etanolic extract of Nothopanax scutellarium. Merr.'s leaves was relative harmless (LD50>15 g/kg BW). The delay toxic effect was seen by any significant changes in body weight on several dasy observation, any significant changes in heart and kidney relative weight.Conclusion: the etanolic extract of Nothopaanax scutellarium. Merr.'s leaves are relative harmless and influence relative weight of heart and kidney.