Herb for Diabetes
Daftar Isi:
- Introduction: Diabetes mellitus is one of the disease of aging attributed to chronic inflammation is characterized by increasing blood glucose levels, usually with increasing free radical that can damage pancreas which can be neutralized by antioxidant. Some medicinal plants, have antioxidant effect and have been used empirically by community for controlling blood sugar in Diabetes patient.Objective: to know hypoglycemic effect of water extract of Andrographis paniculata Nees, Morinda citrifolia Linn, Strobilanthes crispus Bl, Aloe vera L, Persea americana Mill, Orthosiphon spicatus Backer, Phaleria macrocarpa (Scheff) Boerl on mice as diabetes animal model.Method: The research design was prospective comparative true experimental using complete random design. The method was diabetic test in alloxan (120 mg/kg bwt, i.v) induced Swiss Webster diabetic mice that given the variation herbs water extract with oral administration and glibenclamide as long as 7 days Data measured are blood glucose levels/BGL (mg/dL) after allloxan induced and after the treatment. Percentage in lowering blood glucose levels data analyzed used ANOVA on ranks continued by Dunnett's Multiple Comparisons, a=0.04 .Result: There is lowering BGL after treatment with Andrographis paniculata Nees (29.33%), Morinda citrifolia Linn (15.50%), Strobilanthes crispus Bl (12.50%), Aloe vera L (40,46%), Persea americana Mill (44,44%), Orhtosiphon spicatus Backer (43.34%), Phaleria macrocarpa (Scheff) Boefl (34.51%) that is significantly difference compared to negative control (-1.58%) (p<0,05).Conclusion: Andrographis paniculata Nees, Morinda citrifolia Linn, Strobilanthes crispus Bl, Aloe vera L, Persea americana Mill, Orthosiphon spicatus Backer, Phaleria macrocarpa (Scheff) Boerl have hypoglycemic effect on alloxan induced Swiss Webster mice.