Peptic Ulcer Prevention in Female Wistar Rat with Gel From Cincau Hijau Fresh Leaves (Cyclea barbata MIERS.)
| Main Authors: | Sulamanda, Shendy Chandra; School of Pharmacy, Institut Teknologi ITB, Fidrianny, Irda; School of Pharmacy, Institut Teknologi Bandung, Soemardji, Andreanus A. |
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| Format: | application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Jurnal Medika Planta
, 2013
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| Subjects: | |
| Online Access: |
http://majour.maranatha.edu/index.php/jmp/article/view/871 |
Daftar Isi:
- Introduction: Cyclea barbata leaves is used traditionally as a peptic ulcer prevention.Objective of this research is to evaluate the effect based on pharmacology.Methdo: Rat-peptic ulcer model was induced with cold-water immersion method at 20C. The extract was extracted by squeezing and was given before peptic ulcer induced. Parameter test were based on severity and number of ulcer. Animal test group are positive control Tween-80 20mL/kg body-weight, standard sucralfate 90 mg/kg body-weight, extract 375, 750, and 1599 mg/kg body weight.Result: Based on the severity score, all dosages of extract have preventive effect showed the significant severity reduction of peptic ulcer (p<0.05) with positive control. Base on number of ulcer, the dose of 375 mg/kg body-weight of this extract have preventive effect showed the significant number reduction of peptic ulcer (p<0.05) with positive control. Conclusion: The dose of 375 mg/kg body-weight of this extract gives the percentage of ulcer prevention and the effectiveness percentage of ulcer preventive dose based on standard, higher than the dose of 750 and 1500 mg/kg body-weight.