Effect of Methanol Extract Hearhleaf Madeiravine (Anredera cordifolia (Ten.) Steenis) Leaves on Blood Sugar in Diabetes Mellitus Model Mice
| Main Authors: | Sukandar, Elin Yulinah; School of Pharmacy, Institut Teknologi Bandung, Qowiyyah, Atun; Department of Pharmacy, Garut University, Larasari, Lady; Department of Pharmacy, Garut University |
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| Format: | application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Jurnal Medika Planta
, 2013
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| Subjects: | |
| Online Access: |
http://majour.maranatha.edu/index.php/jmp/article/view/851 |
Daftar Isi:
- Heartleaf madeiravine (Anredera cordifolia (Ten.) Steenis) leaves, traditionally, are used to treat various diseases including to decrease blood glucose level.Objective: This study aims to determine the effect of heartleaf madeiravine leaves extract in lowering blood glucose level and in repairing a damage of -pancreas cells. Methods : This experimental research uses Swiss Webster mice The extract was tested on diabetic Swiss Webster mice induced by alloxan at a dose of 70 mg/kg bw intravenously . Doses used for treating these mice were 50 mg/kg bw and 200 mg/kg bw orally for 14 days .Blood glucose level of the mice were measured after 7 and 14 days administration of the extract. The pancreas cell of treated mice were observed histologicaly on day 14. Result: The research showed that the methanol extract of heartleaf madeiravine leaves at a dose of 50, 100 and 200 mg/kg bw could lower blood glucose level significantly different compared to control group (p<0.05) either on day 7 or on day 14 and increased the number and repaired the damage of - pancreas cell. Conclusion: Methanol extract of heartleaf madeiravine leaves can be used to treat diabetes mellitus induced by alloxan in mice.