Effect Tithonia divesifolia (Hemley) A. Gray) Ethanol Extract as Antimalarial on Mice Strain Balb/C Before and After Infected by Plasmodium berghei
| Main Authors: | Utami, Wiwien Sugih; Jember University, Faculty of Medicine, -, Nuri; Jember University, Faculty of Pharmacy, Pharmacy Biology, Armiyanti, Yunita; Jember University, Faculty of Medicine |
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| Format: | application/pdf eJournal |
| Bahasa: | ind |
| Terbitan: |
Jurnal Medika Planta
, 2013
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| Subjects: | |
| Online Access: |
http://majour.maranatha.edu/index.php/jmp/article/view/840 |
Daftar Isi:
- Introduction.Antimalarial resistance of Plasmodium sp encourage the study of new antimalarial drugs, sush as the traditional medicinal plants used to treat malaria, kembang bulan (Tithonia diversifolia (Hemsley) A. Gray). Kembang bulan (Tithonia diversifolia (Hemley) A. Gray) ( Asteraceae family) have activity as an antimalarial, anti-inflammatory and analgesic. In vitro, ethanol extract of these leaf had been proven that it was active in inhibiting the growth of P. berghei at doses of 40; 80; 160; and 320 mg/kg body weight with IC50 values of 114 mg / kg body weight and the IC90 of 475 mg/kg body weight. Tithonia diversifolia extract contains of substances that could be used as an antimalarial prophylactic and curative in malaria. Objective: to determine the effect of ethanol extract of leaf development as a antimalaria month. Methods is observing the effect of ethanol extract of kembang bulan to parasitemia levels on mice Balb / C before and after infection by the parasite Plasmodium berghei (parasitemia degree of mild, moderate and severe. Result. Based on data from the various percentages of inhibition of extract ethanol of kembang bulan leaf for growth in P. berghei before infected and at various stadium of infection (mild, moderate, and severe), can be seen that in the prophylaxis group had the greatest percentage of inhibition. Conclusion. The Tithonia diversifolia leaves ethanol extract have antimalarial activity in mice Balb/c before inoculated Plasmodium berghei (prophylaxis) and after mild (1%), moderate (5%), and severe (10%).