Phylogeny magnitude of Mycobacterium tuberculosis based on genomic analysis
| Main Authors: | Yanti, Budi, Mulyadi, Mulyadi, Soetjipto, Soetjipto, Mertaniasih, Ni Made, Amin, Muhammad |
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| Other Authors: | personal |
| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Faculty of Medicine, Universitas Islam Indonesia
, 2020
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| Subjects: | |
| Online Access: |
https://journal.uii.ac.id/JKKI/article/view/13652 https://journal.uii.ac.id/JKKI/article/view/13652/pdf https://journal.uii.ac.id/JKKI/article/downloadSuppFile/13652/1716 https://journal.uii.ac.id/JKKI/article/downloadSuppFile/13652/1760 https://journal.uii.ac.id/JKKI/article/downloadSuppFile/13652/1761 https://journal.uii.ac.id/JKKI/article/downloadSuppFile/13652/1762 https://journal.uii.ac.id/JKKI/article/downloadSuppFile/13652/1763 |
Daftar Isi:
- Mycobacterium tuberculosis (MTB) is mostly found in humans, and it can cause more than two million deaths each year with increasing morbidity. Although lineages of MTB show identical nucleotide relationships, they have different characteristics such as evolution, transmission, drug resistance, host interaction, latency, and vaccine effectiveness. It is necessary to have better understanding of MTB relationships based on similarities in genome sizes and phylogenetic analysis. This paper observes the relationships of MTB based on nucleotide through phylogenetic frameworks. The MTB species consist of six lineages, and each lineage has various size of genomes . This difference contributes to virulence of MTB affecting levels of severity, morbidity, and mortality of diseases. Genetic diversity of MTB can contribute to global threats in the world such as outbreak of tuberculosis, Multi Drug Resistant (MDR) and Extensively Drug Resistant (XDR) tuberculosis.
- Mycobacterium tuberculosis mostly obligate pathogen in humans and causes more than 2 million deaths each year with high degree of morbidity. The lineage of Mycobacterium tuberculosis has a level of nucleotide relevancy which is almost similar with its inheritance. However, a broad comprehension on phylogeny magnitude of Mycobacterium tuberculosis based on the analysis of similarity in genomic size would be a critical point in management of tuberculosis. The significance of genetic relationship could be compared with among size of genomic, biological potential in evolution history, and pathogenesis of a disease. Each strain in the world derived from many lineages of microorganism with various genetic structure and typical virulence ability which are impacted to diagnosis of disease, powerful of treatment, and vaccination. The genetic diversity of Mycobacterium tuberculosis has a special awareness because it could be a nebulous trigger for the emergence of global threats in the world such as outbreak of tuberculosis, MDR (Multi Drug Resistant) dan XDR (Extensively Drug Resistant) of tuberculosis.