Sulforaphane Prevents Colitis-associated Cancer by Inducing Phase II Enzymes Activity of Liver Detoxification
| Main Authors: | Khiong, Khie; Biology Department/Immunology Division of Central Medical Research, Medical Faculty of Maranatha Christian University, Darsono, Lusiana; Pharmacology Department, Medical Faculty of Maranatha Christian University, Yolanda, Raissa; Medical Faculty of Maranatha Christian University |
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| Format: | application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Universitas Kristen Maranatha
, 2013
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| Online Access: |
http://majour.maranatha.edu/index.php/jurnal-kedokteran/article/view/906 |
Daftar Isi:
- Ulcerative colitis (UC) is a kind of Inflammatory Bowel Disease (IBD) characterized by chronic inflammation that causes ulceration of the colonic mucosa and extends proximally from the rectum into the colon. In patients with prolonged and extensive colitis involving the entire organ, the risk for colorectal cancer is increasing. Consumption of cruciferous vegetables reduces the risk of cancer such as colorectal cancer by reducing early stage of inflammation due to its phytonutrien compounds. Sulforaphane is an organosulfur compound classified as an isothiocyanate that can prevent UC and colorectal cancer. Sulforaphane induces phase II enzyme and inhibit enzymes involved in carcinogenesis. Sulforaphane may also offer special protection to those with colon cancer susceptible genes.