Transduksi Sinyal Hormon Kolesistokinin sebagai Target untuk Mengatasi Obesitas
| Main Authors: | Hidayat, Meilinah; Divisi Ilmu Gizi Fakultas Kedokteran Universitas Kristen Maranatha, Jl. Prof Suria Sumantri 65 Bandung 40163 Indonesia, Sujatno, Muchtan; Fakultas Kedokteran Universitas Padjadjaran, Bandung, ., Nugraha; Fakultas Kedokteran Universitas Padjadjaran, Bandung, ., Setiawan; Fakultas Kedokteran Universitas Padjadjaran, Bandung |
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| Format: | application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Universitas Kristen Maranatha
, 2012
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| Online Access: |
http://majour.maranatha.edu/index.php/jurnal-kedokteran/article/view/830 |
Daftar Isi:
- In the last decade, the number of overweight children and adults has increased all over the world. In Indonesia, obesity needs serious management because it is multi-factorial etiology. One of the predominant factors of obesity is excessive-appetite. This paper aims to discuss a gut hormone called cholecystokinin (CCK), which has been proven to be able to decrease appetite. CCK has a short term anorectic effect, which becomes the reason for the hormone to be one of therapeutic targets of obesity in the future. CCK is produced in the enteroendocrine cell along the small gut mucous and the secretion is stimulated by protein and fat through signal transduction mechanisms called G Protein Coupling Receptor (GPCR), GPR 93. Then they activate Extracellular Signal-Related Kinase (ERK) 1/2 through Gαq and Gαi signal transduction. Soybean contains a bioactive protein, β-conglycinin (BconP) subunit–β, which has been proven to be the best inducer for CCK secretion. The well-known signal transduction pathway is Gαq-coupled GPCR, which influences the calcium signal and activates Protein Kinase C (PKC). However, the downstream signaling to complete the pathway remains unclear and further study will be needed to explore the whole process. Keywords: signal transduction, cholecystokinin, fat, protein, β-conglycinin