Pengaruh Kombinasi Ekstrak Umbi Lapis Bawang Putih dan Ekstrak Rimpang Kunyit terhadap Janin Mencit Swiss-Webster
| Main Authors: | Sukandar, Elin Yulinah; Institut Teknologi Bandung, Fidrianny, Irda; Institut Teknologi Bandung, Garmana, Afrillia Nuryanti; Institut Teknologi Bandung |
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| Format: | application/octetstream eJournal |
| Bahasa: | eng |
| Terbitan: |
Universitas Kristen Maranatha
, 2010
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| Online Access: |
http://majour.maranatha.edu/index.php/jurnal-kedokteran/article/view/122 |
Daftar Isi:
- The influence of solution of garlic (Allium sativum L.) in water and solution of turmeric (Curcuma domestica Val.) in ethanol had been studied in pregnant Swiss-Webster mice. The garlic and turmeric extract were administered orally at dose level combination of 100:100, 500:500, and 1000:1000 mg/kg body weight on day sixth to fifteenth of gestation. The mother was sacrified on day eighteenth day of gestation to observe life fetus, resorption, and growth failure. One third of the fetuses were eviscerated for skeletal staining with alizarin red and two third of the fetuses were hardened with Bouin’s fixation solution. No malformation were found in the eviscerated group. Resorption of 1.11 % fetuses and 1.11 % growfail fetuses showed by extract combination of 100:100 mg/kg body weight. Growfail Growth failure of 4.59 % fetuses showed by extract combination of 500:500 mg/kg body weight. Resorption of 0.96 % fetuses showed by extract combination of 1000:1000 mg/kg body weight. The conclusion of this study, is that the combination of turmeric and garlic extract of 100:100 mg/kg body weight, which is equivalent to usual dose in human showed safe as herbal medicine, while in higher dose it is not recommended for pregnant woman.