Peran Gen p63 dalam Regulasi Proliferasi Sel
| Main Author: | Wargasetia, Teresa Liliana; Universitas Kristen Maranatha |
|---|---|
| Format: | application/octetstream eJournal |
| Bahasa: | eng |
| Terbitan: |
Universitas Kristen Maranatha
, 2010
|
| Online Access: |
http://majour.maranatha.edu/index.php/jurnal-kedokteran/article/view/115 |
Daftar Isi:
- p63 gene that exits in chromosome 3q27-28 has two promoters and three different C ends, namely a, b, and g so that the transcription of p63 gene produces 6 variants. Various researches show that p63 gene plays a role in inducting the stoppage of cell cycles in the form of G1 arrest and G2 arrest. The products of p63 gene also have a role in activating the extrinsic/death receptor-mediated apoptosis pathway and the intrinsic/mitochondria-mediated apoptosis pathway. Understanding of the role of p63 gene in regulating cell proliferation and the synergic effect of p63 and chemotherapy medicines is essential to develop strategies for cancer therapy.