The 8q24 Rs10090154c>T Gene Variant and Its Association with the Risk of Prostate Cancer: A Systematic Review and Meta-analysis
| Main Author: | B. Prasetyawan, - |
|---|---|
| Format: | Article NonPeerReviewed |
| Online Access: |
http://repository.ub.ac.id/187404/ |
Daftar Isi:
- Objective: Genetic variation at chromosome 8q24 is considered as the potential biomarker for prostate cancer. We aimed to assess the relation between the gene variant of 8q24 rs10090154C>T and the risk of prostate cancer. Material and Methods: A meta-analysis was carried out in January to June 2020 by collecting relevant studies through online databases. The correlation and estimated effect between the gene variant of 8q24 rs10090154C>T and the risk of prostate cancer were analyzed using a Z test. Results: A total of 16 relevant studies were selected (16,842 cases and 18,258 controls). In overall, T allele and CT genotype of 8q24 rs10090154C>T gene polymorphism increased the risk of prostate cancer (OR95%CI=1.238 [1.14-1.34], pT was associated with increased risk of prostate cancer (OR95%CI=1.285 [1.07-1.54], pT was correlated with increased risk of prostate cancer (OR95%CI=1.302 [1.17-1.45], pT gene polymorphism had strong association with the risk of prostate cancer.