The experimental study of TNF-α & CRP expression in the spinal tuberculosis after instrumentation
| Main Author: | T. Risantoso, - |
|---|---|
| Format: | Article NonPeerReviewed |
| Online Access: |
http://repository.ub.ac.id/187242/ https://doi.org/10.1016/j.amsu.2021.103048 |
Daftar Isi:
- Previously, the management of spinal TB was using drugs and external stabilization. Surgical techniques were developed afterwards to clean the infected vertebral segment. The TB treatment approach is now based on immunology because the bacteria Mycobacterium tuberculosis has unique characteristics and the increasing cases of MDR (multiple drug resistant) TB due to mutation processes. TNF-α and CRP has a major role in immune activity of spinal TB. The energy from metal devices composed of ions and particles that have been used in instrumentation is expected to reduce the biomolecular and biocellular activity of the spinal tuberculosis inflammation activity. This study aims to investigate TNFα and CRP value as evaluator of bone inflammation activity in Spinal TB through experimental studies in Laboratory at Veterinary Faculty, Universitas Brawijaya