Efek Antifungal Ekstrak Etanol Daun Sirsak (Annona Muricata) Pada Pertumbuhan Candida Albicans In Vitro
Daftar Isi:
- Candidiasis Is A Condition Commonly Caused By C andida Albicans And Is Present As Normal Flora In The Skin And Mucous Membranes. It Can Grow Out Of Control And Cause Candidiasis When There Are Body Environment Changes. The Prevention Of Futher Complication And Treatment Focus Is On How To Combat The Organism In Susceptible Persons Effectively. Annona Muricata Possesses Active Substances Such As Annonaceous Acetogenins, Gentisic Acid And Condensed Tannins Which Could Induce The Death Of Candida Albicans Cells And Is Belived To Be An Alternative Treatment For Candidiasis. The Objective Of This Research Was To Determine The Effect Of Annona Muricata Leaf Ethanol Extract On The Growth Of Candida Albicans In Vitro. The Research Design Used Was Experimental Laboratory Study Using The Tube Dilution Test On Sabouraud’s Dextrose Broth Medium To Determine The Minimum Inhibitory Concentration (MIC) And The Streaking Stage On A Sabouraud’s Dextrose Agar Plate To Determine The Minimum Fungicidal Concentration (MFC). The Annona Muricata Leaf Extract Concentration Used Were 32.5%, 35%, 37.5%, 40%, 42.5% And 45%. The Results Were Analyzed Using The One-Way ANOVA. The Fungicidal Concentration Of Annona Muricata Extract Is 45% And The Correlation Coefficient, R = -0.956 Shows That There Is Decrease In The Colony Number As The Concentration Increases. In Conclusion, Annona Muricata Leaf Ethanol Extract Inhibits Candida Albicans And Could Be Used As An Alternative Anti-Fungal Treatment For Candidiasis