Synthesis, Antiproliferative Activity and Molecular Docking Studies of 1,3,5-Triaryl Pyrazole Compound as Estrogen α Receptor Inhibitor Targeting MCF-7 Cells Line
| Main Authors: | Herfindo, Noval, Prasetiawati, Riska, Sialagan, Daniel, Frimayanti, Neni, Zamri, Adel |
|---|---|
| Format: | Article info application/pdf Journal |
| Bahasa: | eng |
| Terbitan: |
Universitas Jenderal Soedirman
, 2020
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| Online Access: |
https://ojs.jmolekul.com/ojs/index.php/jm/article/view/585 https://ojs.jmolekul.com/ojs/index.php/jm/article/view/585/323 https://ojs.jmolekul.com/ojs/index.php/jm/article/downloadSuppFile/585/57 |
Daftar Isi:
- This research has been successfully synthesized three compounds of 1,3,5-triaryl pyrazole derivatives by two steps reaction. Firstly, pyrazoline (4a-c) compound was obtained by one-pot reaction of aromatic ketones, aldehyde and hydrazine in basic condition. Then, pyrazole (5a-c) compound was obtained by oxidative aromatization of compound 4 in the presense of acetic acid. Chemical structure of predicted molecules was confirmed by FTIR, NMR and HRMS spectroscopy data analysis. Antiproliferative activity of compound 5a-c were evaluated by in vitro assay against MCF-7 cells line and molecular docking simulation against ERα (PDB ID: 3ERT) using MOE 2019. Biological evaluation result showed that pyrazole compounds had weak antiproliferative activity against MCF-7 cells with IC50 were > 1000 μM, whereas the docking studies agrees the result.