Cytotoxic Steroids from The Stem Bark of Chisocheton cumingianus (Meliaceae)
| Main Authors: | Katja, Dewa Gede, Farabi, Kindi, Nurlelasari, Nurlelasari, Harneti, Desi, Julaeha, Euis, Hidayat, Ace Tatang, Mayanti, Tri, Maharani, Rani, Supratman, Unang, Awang, Khalijah |
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| Format: | Article info application/pdf Journal |
| Bahasa: | eng |
| Terbitan: |
Universitas Jenderal Soedirman
, 2017
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| Subjects: | |
| Online Access: |
https://ojs.jmolekul.com/ojs/index.php/jm/article/view/257 https://ojs.jmolekul.com/ojs/index.php/jm/article/view/257/246 |
Daftar Isi:
- Three cytotoxic steroids, stigmasterol (1), stigmast-5-en-3b-ol (2) and b-sitosterol-3-O-acetate (3) were isolated from the stem bark of Chisocheton cumingianus. The chemical structures of those compounds were identified based on spectroscopic data and by comparison with those data previously reported. All of the compounds isolated were evaluated for their cytotoxic effects against P-388 murine leukemia cells in vitro. Compounds 1-3 showed cytotoxicity activity against P-388 murine leukemia cells with IC50values of 12.4, 60.8, and ÃÂ 100 mg/mL, respectively.