Pengaruh Variasi Konsentrasi Hidroxy Propyl Methyl Cellulose (HPMC) terhadap Stabilitas Fisik Gel Ekstrak Tembakau (Nicotiana tabaccum L.) dan Aktivitasnya terhadap Streptococcus mutans
| Main Authors: | Yati, Kori; Universitas Muhammadiyah Prof. DR. HAMKA, Jufri, Mahdi; Universitas Indonesia, Gozan, Misri; Universitas Indonesia, Wahid, Mardiastuti; Universitas Indonesia, Dwita, Lusi; Universitas Muhammadiyah Prof. DR. HAMKA |
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| Format: | Article info application/pdf Journal |
| Bahasa: | eng |
| Terbitan: |
Directorate of Research and Community Engagement, Universitas Indonesia
, 2018
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| Subjects: | |
| Online Access: |
http://psr.ui.ac.id/index.php/journal/article/view/4146 http://psr.ui.ac.id/index.php/journal/article/view/4146/691 http://psr.ui.ac.id/index.php/journal/article/downloadSuppFile/4146/1139 http://psr.ui.ac.id/index.php/journal/article/downloadSuppFile/4146/1140 http://psr.ui.ac.id/index.php/journal/article/downloadSuppFile/4146/1141 |
| ctrlnum |
article-4146 |
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<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><title lang="en-US">Pengaruh Variasi Konsentrasi Hidroxy Propyl Methyl Cellulose (HPMC) terhadap Stabilitas Fisik Gel Ekstrak Tembakau (Nicotiana tabaccum L.) dan Aktivitasnya terhadap Streptococcus mutans</title><creator>Yati, Kori; Universitas Muhammadiyah Prof. DR. HAMKA</creator><creator>Jufri, Mahdi; Universitas Indonesia</creator><creator>Gozan, Misri; Universitas Indonesia</creator><creator>Wahid, Mardiastuti; Universitas Indonesia</creator><creator>Dwita, Lusi; Universitas Muhammadiyah Prof. DR. HAMKA</creator><subject lang="en-US">tembakau extract; gel; HPMC; Streptococcus mutans</subject><description lang="en-US">Tobacco extract had been proven to have antimicrobial activity against Streptococcus mutans. To maximize the use of tobacco extract on topical use as an antibacterial, it could be formulated into a pharmaceutical preparation. This study aimed to formulate tobacco extract in gel preparation by using Hidroxy Propyl Methyl Cellulose (HPMC) as a gelling agent and to test its activity on S. mutans. The tobacco extract gel was prepared in 3 formulas with variations of HPMC concentration of 1.5% (F1), 2% (F2) and 2.5% (F3). The research began with tobacco extraction, then continued with characteristics evaluation. The extract was formulated in gel form and evaluated for 12 weeks of physical stability. Antibacterial activity was tested using the diffusion method. The evaluation results of tobacco extract gel showed that all formulas were stable during 12 weeks storage. Antimicrobial activity against S.mutans showed inhibitory diameter of F1, F2 and F3, were 9,07 mm, 19,53 mm, and 11,57 mm respectively. The test was continued by determining the relative potential of F2 compared to erythromycin. The test results showed 1.2 x 10-2 relative potential compare to erythromycin. Based on the results of this study, it can be concluded that HPMC concentration difference did not give significant difference to the physical stability of tobacco gel, with the best antibacterial activity on S. mutans obtained from F2.</description><publisher lang="en-US">Directorate of Research and Community Engagement, Universitas Indonesia</publisher><date>2018-12-30</date><type>Journal:Article</type><type>Other:info:eu-repo/semantics/publishedVersion</type><type>Other:</type><type>File:application/pdf</type><identifier>http://psr.ui.ac.id/index.php/journal/article/view/4146</identifier><identifier>10.7454/psr.v5i3.4146</identifier><source lang="en-US">Pharmaceutical Sciences and Research (PSR); Vol 5, No 3 (2018); 133-141</source><source>2477-0612</source><source>2407-2354</source><language>eng</language><relation>http://psr.ui.ac.id/index.php/journal/article/view/4146/691</relation><relation>http://psr.ui.ac.id/index.php/journal/article/downloadSuppFile/4146/1139</relation><relation>http://psr.ui.ac.id/index.php/journal/article/downloadSuppFile/4146/1140</relation><relation>http://psr.ui.ac.id/index.php/journal/article/downloadSuppFile/4146/1141</relation><rights lang="en-US">Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).</rights><recordID>article-4146</recordID></dc>
|
| language |
eng |
| format |
Journal:Article Journal Other:info:eu-repo/semantics/publishedVersion Other Other: File:application/pdf File Journal:Journal |
| author |
Yati, Kori; Universitas Muhammadiyah Prof. DR. HAMKA Jufri, Mahdi; Universitas Indonesia Gozan, Misri; Universitas Indonesia Wahid, Mardiastuti; Universitas Indonesia Dwita, Lusi; Universitas Muhammadiyah Prof. DR. HAMKA |
| title |
Pengaruh Variasi Konsentrasi Hidroxy Propyl Methyl Cellulose (HPMC) terhadap Stabilitas Fisik Gel Ekstrak Tembakau (Nicotiana tabaccum L.) dan Aktivitasnya terhadap Streptococcus mutans |
| publisher |
Directorate of Research and Community Engagement, Universitas Indonesia |
| publishDate |
2018 |
| topic |
tembakau extract gel HPMC Streptococcus mutans |
| url |
http://psr.ui.ac.id/index.php/journal/article/view/4146 http://psr.ui.ac.id/index.php/journal/article/view/4146/691 http://psr.ui.ac.id/index.php/journal/article/downloadSuppFile/4146/1139 http://psr.ui.ac.id/index.php/journal/article/downloadSuppFile/4146/1140 http://psr.ui.ac.id/index.php/journal/article/downloadSuppFile/4146/1141 |
| contents |
Tobacco extract had been proven to have antimicrobial activity against Streptococcus mutans. To maximize the use of tobacco extract on topical use as an antibacterial, it could be formulated into a pharmaceutical preparation. This study aimed to formulate tobacco extract in gel preparation by using Hidroxy Propyl Methyl Cellulose (HPMC) as a gelling agent and to test its activity on S. mutans. The tobacco extract gel was prepared in 3 formulas with variations of HPMC concentration of 1.5% (F1), 2% (F2) and 2.5% (F3). The research began with tobacco extraction, then continued with characteristics evaluation. The extract was formulated in gel form and evaluated for 12 weeks of physical stability. Antibacterial activity was tested using the diffusion method. The evaluation results of tobacco extract gel showed that all formulas were stable during 12 weeks storage. Antimicrobial activity against S.mutans showed inhibitory diameter of F1, F2 and F3, were 9,07 mm, 19,53 mm, and 11,57 mm respectively. The test was continued by determining the relative potential of F2 compared to erythromycin. The test results showed 1.2 x 10-2 relative potential compare to erythromycin. Based on the results of this study, it can be concluded that HPMC concentration difference did not give significant difference to the physical stability of tobacco gel, with the best antibacterial activity on S. mutans obtained from F2. |
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Universitas Indonesia |
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KOTA DEPOK |
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JAWA BARAT |
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