EFFECT OF EXON 1 CODON 52 AND 54 MANNOSE BINDING LECTIN GENE POLYMORPHISM ON THE INCIDENCE OF PULMONARY TUBERCULOSIS

Main Authors: K. Arrahmanda, -, Z. Ahmad, -, Sudarto, -, A. Rasyid, -, Yuwono, -
Format: Proceeding PeerReviewed application/pdf
Terbitan: , 2011
Subjects:
Online Access: http://eprints.unsri.ac.id/1784/1/Shanghai_3.pdf
http://eprints.unsri.ac.id/1784/
Daftar Isi:
  • Tuberculosis (TB) still world’s and Indonesia problem. Approximately one third of the world population ever infected with Mycobacterium tuberculosis (Mtb), but only about 10% become pulmonary TB. Presumably there is influence of individual genetic factors to TB infection. Mannose binding lectin (MBL) is an acute phase protein in a non specific immune system response which will bind Mtb and activate complement system to destroy the pathogen. Polymorphisms in exon 1 codon 52 and 54 might have correlation with decreasing of MBL protein in plasma and influence to opsonin function