Efek Asam Metoksiasetat (MAA) Terhadap Perkembangan Embrio Tahap Praimplantasi Mencit (Mus musculus) Swiss Webster
| Main Author: | Riyanto, Riyanto |
|---|---|
| Format: | Article PeerReviewed application/pdf |
| Terbitan: |
Universitas Sriwijaya
, 2003
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| Subjects: | |
| Online Access: |
http://eprints.unsri.ac.id/1627/1/Efek_MAA_tehadap_Embrio_Praimplantasi_Mus_musculus__lektor_.pdf http://www.fkip.unsri.ac.id/ http://eprints.unsri.ac.id/1627/ |
Daftar Isi:
- The effects of methoxyacetic acid on preimplantation stage embryos of Swiss Webster mice (Mus musculus) have been studied. Female mice were superovulated with 5 I.U. of PMSG (Folligon) and 5 I.U. of hCG (Chorulon) and were mated with male mice overnight. A veginal plug detected at the following morning was confirmed as day 0 of gestation. On gestation day 2, mice were administered with MAA dose 2.5 mmol/kg bw by gevage. On gestation day 3.5 mice were sacrificed for embryo collection. The result showed that MAA could decrease significantly (p<0,05) the number of embryos that reached late blastocysts, this was caused by significant increase (p<0,05) of the percentege of embryos that could only reach the morula stage. It could be concluded, that the administration of MAA on gestation day 2 inhibit the developmental of preimplantation embryos, proven by the decrease of percentage of embryos that reached late blastocysts stage caused by developmental retardation, especially on the morula stage.