EFFECT OF D543N AND TGTG DELETION 3’ UTR Nramp1 GENE POLYMORPHISMS AGAINST PULMONARY TUBERCULOSIS AT MELAYU ETHNIC OF SOUTH SUMATERA
| Main Author: | -, Yuwono |
|---|---|
| Format: | Proceeding PeerReviewed application/pdf |
| Terbitan: |
, 2010
|
| Subjects: | |
| Online Access: |
http://eprints.unsri.ac.id/1483/1/Eijkman.pdf http://eprints.unsri.ac.id/1483/ |
Daftar Isi:
- Pulmonary tuberculosis is still a major health problem with incidence on the world each year 139/100000 population and caused 1,8 million people death.Immunological finding showed that only 10% of population infected by Mycobacterium tuberculosis will get pulmonary tuberculosis, 90% were not get the disease. It is indicated that genetic factors controlling immune responses have major role in the pathogenesis of tuberculosis. Some studies showed 3 kind of genes have major contribution: Mbl gene encoding surface protein in attachment process. Nramp1 gene encoding protein in phogolysosome, responsible for phagocytosis process and Vdr gene encoding protein that regulate cellular immunity.