The Role of Tumor Necrosis Factor (TNF ) and Matrix Metalloproteinase9 (MMP9) Serum in Preterm Premature Rupture of Membranes
| Main Authors: | Ardiles, Ardiles, Desmiwarti, Desmiwarti, Bachtiar, Hafni |
|---|---|
| Format: | Article info application/pdf Journal |
| Bahasa: | eng |
| Terbitan: |
Indonesian Society of Obstetrics and Gynecology
, 2017
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| Online Access: |
http://inajog.com/ojs/index.php/journal/article/view/558 http://inajog.com/ojs/index.php/journal/article/view/558/474 |
Daftar Isi:
- Objective: To investigate the role of TNF- and MMP-9 serumin preterm premature rupture of membranes (PPROM).Methods: We used cross-sectional study design. Subjects were allpregnant women with and without PPROM who underwent checkup at Obstetrics and Gynecology Functional Medical Staff GeneralHospital Dr. M. Djamil and networking hospital.Results: A total of 48 subjects were enrolled in this study. Themean serum levels of TNF- in patients with PPROM 17.43ng/ml 12.4 ng/ml and without PPROM 8.45 ng/ml 6.86ng/ml. The mean serum levels of MMP-9 in patients withPPROM 8.77 ng/ml 4.41 ng/ml, and without PPROM 4.46ng/ml 3.04 ng/ml. Statistical test result p value <0.05, it canbe conclude there are differences in the levels of TNF- andMMP-9 serum in premature rupture of membranes and withoutpremature rupture of membranes pregnancy of preterm.Conclusion: There are differences in the levels of TNF- andMMP-9 serum in PPROM and without PPROM.[Indones J Obstet Gynecol 2017; 5-4: 199-202]Keywords: MMP-9, premature rupture of membranes, TNF-