Oral erythromycin for treatment of gastrointestinal dysmotility in premature infants
| Main Authors: | Moesri, Armelia, Lubis, Bugis Mardina, Asrul, Asrul, Sinuhaji, Atan Baas, Tjipta, Guslihan Dasa |
|---|---|
| Format: | Article info application/pdf eArticle |
| Bahasa: | eng |
| Terbitan: |
Indonesian Pediatric Society
, 2007
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| Online Access: |
https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/421 https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/421/304 |
Daftar Isi:
- Background Functional immaturity of gastrointestinal (GI)motility predisposes preterm infants to feeding intolerance.Erythromycin as a prokinetic agent has been given to preterminfants for the management of non-obstructive GI dysmotility.Objective To evaluate the efficacy of oral erythromycin for thetreatment of GI dysmotility in preterm infants.Methods A randomized controlled clinical trial was done at AdamMalik Hospital and Pirngadi Hospital, Medan, between October2004 – March 2005. Fifty preterm infants with feeding intolerancewere randomly assigned to either receive oral erythromycin (12.5mg/kg, every 6 hours) or placebo for 7 days. Improved tolerancefor enteral feedings was evaluated by the amount of gastric residuebefore feeding.Results On the sixth day, there was a significant difference in theamount of residue from gastric residue between the oralerythromycin group and placebo group (mean 21.7 and 29.4;P<0.05) and so were results on the seventh day (mean 14.1 and26.9; P<0.05).Conclusion Oral erythromycin reduces the amount of gastricresidue before feed in premature infants.