UCP3 gene polymorphism and insulin resistance in obese female adolescents
| Main Authors: | Eurike, Dian, Muhammad, Harry Freitag Luglio, Susilowati, Rina, Julia, Madarina |
|---|---|
| Format: | Article info application/pdf eArticle |
| Bahasa: | eng |
| Terbitan: |
Indonesian Pediatric Society
, 2012
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| Online Access: |
https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/382 https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/382/266 |
Daftar Isi:
- Background A previous study on obese female adolescents inYogyakarta done in the year 2007 suggests that genetic factorsmight influence insulin resistance. One genetic factor that hasbeen associated \\lith insulin resistance in other populations isthe 55C;T polymorphism in the uncoupling protein 3 (UCP3)gene.Objective To investigate an association between the 55C;Tpolymorphism in the UCP3 gene and insulin resistance in obesefemale adolescents in Yogyakarta.Methods A total of79 obese female adolescents were enrolled inthis crosssectional study. Genotyping of the 5 SC/T polymorphismin the UCP3 gene was performed by polymerase chain reactionrestriction fragment length polymorphism (PCRRFLP).Results The TiT homozygous individuals had a higher risk ofinsulin resistance (OR 2.3; 95% CI 0.4 to 14.1), as well as higherfasting insulin concentration and homeostatic model assessmentfor insulin resistance (HOMAIR) compared to individuals v.ithother genotypes. The T allele carriers also had a higher risk ofinsulin resistance (OR 1.3; 95% CI 0.7 to 2.5), as well as higherfasting insulin concentration and HOMA IR compared to Callele carriers. However, none of these results were statisticallysignificant (P > 0.05).Conclusion The TiT genotype and T allele of the UCP3 gene55CiT polymorphism was not significantly associated increasedrisk of insulin resistance in obese female adolescents in Yogyakarta.[Paediatr lndanes. 2012;52:152-6].