Metformin Plus Caloric Restriction Show Anti-epileptic EffectsMediated by mTOR Pathway Inhibition
| Format: | Journal Book |
|---|---|
| Bahasa: | eng |
| Terbitan: |
Springer
, 2018
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| Subjects: | |
| Online Access: |
http://opac.unila.ac.id/ucs/index.php?p=show_detail&id=57672 |
Daftar Isi:
- AbstractCaloric restriction (CR) has anti-epileptic effects in different animal models, at least partially due to inhibition of the mechanisticor mammalian target of rapamycin (mTOR) signaling pathway. Adenosine monophosphate-activated protein kinase(AMPK) inhibits mTOR cascade function if energy levels are low. Since hyper-activation of mTOR participates in epilepsy,its inhibition results in beneficial anti-convulsive effects. A way to attain this is to activate AMPK with metformin. Theeffects of metformin, alone or combined with CR, on the electrical kindling epilepsy model and the mTOR cascade in thehippocampus and the neocortex were studied. Combined metformin plus CR beneficially affected many kindling aspects,especially those relating to generalized convulsive seizures. Therefore, metformin plus CR could decrease measures ofepileptic activity in patients with generalized convulsive seizures. Patients that are obese, overweight or that have metabolicsyndrome in addition to having an epileptic disease are an ideal population for clinical trials to test the effectiveness ofmetformin plus CR.