IFNÎ3 modulates human immunoglobulin receptor expression in lipoaspirate-derived mesenchymal stem cells
| Main Authors: | Dian R. Laksmitawati, Jeanne A. Pawitan, Mohamad Sadikin, Caroline T. Sardjono, Ahmad R. Utomo |
|---|---|
| Format: | Journal Book |
| Bahasa: | eng |
| Terbitan: |
Faculty of Medicine-UI
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| Subjects: | |
| Online Access: |
http://opac.unila.ac.id/ucs/index.php?p=show_detail&id=43378 |
Daftar Isi:
- AbstractBackground: Mesenchymal stem cell (MSC) has been reported to have immunomodulator capacity against autoimmune diseases and to prevent allogenic tissue rejection. Many studies revealed that MSCâs inhibit T cell proliferation and induce immunosuppressive condition through the production of prostaglandins, and interleukin-10. In addition, MSC was reported to reduce circulating autoantibody in autoimmune patients following MSC transfusion. So far, there has been no report stating the presence of Fc receptors (receptors for immunoglobulin) on MSCs. The aim of this study was to reveal the expression of FcÎ3Rs in lipoaspirate-derived MSCs by measuring transcription of FcÎ3R mRNA and whether the expression can be modulated.
- 6 hlm.