PENGARUH PEMBERIAN MINUMAN RINGAN BERKARBONASI TERHADAP PERUBAHAN GAMBARAN HISTOPATOLOGI GINJAL TIKUS PUTIH (Rattus norvegicus) JANTAN GALUR Sprague dawley
| Main Author: | Hanifah Choirunnisa, 1618011008 |
|---|---|
| Format: | Bachelors NonPeerReviewed Book Report |
| Terbitan: |
FAKULTAS KEDOKTERAN
, 2020
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| Subjects: | |
| Online Access: |
http://digilib.unila.ac.id/61181/1/1.%20ABSTRAK.pdf http://digilib.unila.ac.id/61181/2/2.%20SKRIPSI%20FULL.pdf http://digilib.unila.ac.id/61181/3/3.%20SKRIPSI%20FULL%20TANPA%20BAB%20PEMBAHASAN.pdf http://digilib.unila.ac.id/61181/ |
Daftar Isi:
- iii ABSTRACT THE EFFECTS OF CARBONATED SOFT DRINK CONSUMPTION ON KIDNEY HISTOPATHOLOGY CHANGES IN MALE RATS (Rattus norvegicus) Sprague dawley STRAIN By Hanifah Choirunnisa ABSTRACT Background: Carbonated soft drinks are beverages contain of carbon dioxide and other ingredients such as high fructose corn syrup (HFCS). Excessive consumption of HFCS causes various health problems involving multiple organs including the kidneys. The aim to this research is to determine the effects of carbonated soft drinks on kidney histopathological changes in rats. Methods: This research is a post test only control group experimental study using 24 male rats (Rattus norvegicus) Sprague dawley strain which divided into 4 groups, there are the control group (K) allowed to drink aquades ad libitum, P1 is given carbonated soft drinks 3 ml/day, P2 6 ml/day, and P3 12 ml/day for 30 days. Results: The average of renal histopathological damage in group K:1.07, P1:4.53, P2:5.13, and P3:6.10. Data were tested with Shapiro-Wilk, followed b yhomogeneity test and One Way ANOVA test result in p=0,000 (p<0.05). The results of Post Hoc LSD analysis are p<0.05 between groups K with P1, P2, and P3 (p=0.000), P1 with P2 (p=0.023), and P1 with P3 (p=0.001). Conclusion: There is an effect of carbonated soft drinks on kidney histopathological changes of male rats (Rattus norvegicus) Sprague dawley strain. Keyword: carbonated soft drinks, kidney, histopathological changes. iv ABSTRAK PENGARUH PEMBERIAN MINUMAN RINGAN BERKARBONASI TERHADAP PERUBAHAN GAMBARAN HISTOPATOLOGI GINJAL TIKUS PUTIH (Rattus norvegicus) JANTAN GALUR Sprague dawley Oleh Hanifah Choirunnisa ABSTRAK Latar Belakang: Minuman ringan berkarbonasi merupakan minuman yang mengandung karbon dioksida dan beberapa bahan lain di dalamnya seperti high fructose corn syrup (HFCS). Konsumsi zat tersebut secara berlebihan berdampak pada kesehatan berbagai organ termasuk ginjal. Penelitian ini bertujuan untuk mengetahui pengaruh minuman ringan berkarbonasi terhadap perubahan gambaran histopatologi ginjal tikus. Metode: Penelitian ini merupakan penelitian eksperimental dengan desain post test only control group menggunakan sebanyak 24 ekor tikus putih (Rattus norvegicus) jantan galur Sprague dawley yang dibagi menjadi 4 kelompok, yaitu kelompok K diberi aquades secara ad libitum, P1 diberi minuman ringan berkarbonasi dengan dosis 3 ml/hari, P2 6 ml/hari, dan P3 12 ml/hari selama 30 hari. Hasil: Rerata skor gambaran histopatologi ginjal hewan coba yaitu K:1.07, P1:4.53, P2:5.13, dan P3:6.10. Uji statistik yang dilakukan menggunakan uji normalitas Saphiro-Wilk , dilanjutkan uji homogenitas Lavene, dan uji One Way ANOVA p=0,000 (p<0.05). Hasil analisis Post Hoc LSD dengan hasil p<0.05 antara kelompok K dengan P1, P2, dan P3 (p=0.000), P1 dengan P2 (p=0.023), dan P1 dengan P3 (p=0.001). Simpulan: Terdapat pengaruh pemberian minuman ringan berkarbonasi terhadap gambaran histopatologi ginjal tikus putih (Rattus norvegicus) jantan galur Sprague dawley. Kata Kunci: minuman ringan berkarbonasi, ginjal, perubahan histopatologi.