SINTESIS SENYAWA ASAM O-(PROPIONIL)-5-METILSALISILAT DAN UJI AKTIVITAS ANALGESIK PADA MENCIT (Mus musculus)
Daftar Isi:
- SYNTHESIS OF ACID O-(PROPIONIL)-5-METHYLSALICYLIC AND ANALGESIC ACTIVITY TEST ON MICE (Mus musculus) Development of analgesic compounds from acetylsalicylic acid (acetosal) derivatives by using the esterification of acyl halide which reacts between 5-methylcalicylicylic acid with propionylchloride so that it can form O-(propionyl)-5-methylcalicylic acid. Tests carried out by testing the purity of compounds using 3 stages, namely: organoleptic, melting point determination and TLC. Furthermore, the structural identification is the UV-Vis spectrophotometer, IR spectrophotometer, and 1H-NMR spectrometer to ensure the synthesis compound has been formed. Furthermore, analgesic activity test of writhing test method by injecting control compound in the form of 0.5% CMC-Na solution, test compound in the form of O-(propionyl)-5-methylcalicylic acid suspension at a dose of 25, 50, and 100 mg / kg body weight, and acid suspension acetylsalicylate with a dose of 25, 50, and 100 mg / kg body weight, analyzed with one way ANOVA with α = 0.05, the results obtained by ED50 obtained results of 164.17 mg/kg body weight in acetylsalicylic acid compounds, while 74.13 mg / kg body weight in compounds the results of the synthesis of O-(propionyl)-5-methylcalicylic acid, the conclusion is that O-(propionyl)-5-methylcalicylic acid has better or higher analgesic activity than acetylsalicylic acid.