Pengaruh Ekstrak Biji Pala (Myristica fragrans Houtt) Terhadap Pertumbuhan Pityrosporum ovale Secara In Vitro
Daftar Isi:
- Background: Pityriasis versicolor is a fungal infection of the skin caused by Pityrosporum ovale with prevalence reached 50% in tropical countries in the world. The treatment of Pityriasis versicolor such as azole group has some side effects such as vomit, pruritus and abdominal pain and also resistant, so researchers used nutmeg extract (Myristica fragrans Houtt) extract contains essential oil, flavonoid, saponin, tannin and alkaloid that suspected can play a role as antifungal through different mechanism. Objective : To determine the effect of Nutmeg (Myristica fragrans Houtt) extract on the growth of Pityrosporum ovale in vitro. Methods : Experimental post test only group desing was applied in this study by using dilution tubes with Nutmeg extract concentration of 100%, 50%, 25%, 12,5%, 6,25%, 3,125%, 1,56%, 0,78%, 0,39% and 0%. Data were analyzed using One Way Anova test and continued by using Post Hoc Games Howell test. Results: This research showed Minimum Inhibitory Concentration (MIC) was 3,125%, while Minimum Fungicidal Concentration was 12,5%. One Way Annova test showed p=0,000 which means there are significant impact of the nutmeg extract. Post Hoc Games Howell test showed p<0,05 start from 0,39% and forth which means nutmeg extract give the effect to a decrease in the colony of P. ovale. Conclusion : Nutmeg (Myristica fragrans Houtt) extract has an effect on Pityrosporum ovale growth in vitro.