PENGARUH EKSTRAK KURMA (Phoenix dactilyfera) VARIETAS ‘AJWA TERHADAP JUMLAH INFILTRASI SEL RADANG PADA GINJAL TIKUS YANG DIINDUKSI KOTRIMOKSAZOL
Daftar Isi:
- Ghifari, Miftakhu, 2020. The Effect of Date Palm (Phoenix dactylifera) extract ‘ajwa varieties to the amount of inflammatory cell infiltration on rat kidneys which induced by Cotrimoxazole. Thesis. Faculty of Medicine, University of Muhammadiyah Malang. Supervisor: (I) Hanna Cakrawati* (II) Andi Abdillah ** Background: Acute Interstitial Nephritis (AIN) is the third cause of acute renal failure. 75% of AIN is caused by pharmacological agents such as the side effects of cotrimoxazole. Date palm is an antioxidant which can protect from the damage of oxidative stress therefore, it prevents the enhancement of inflammatory cell infiltration in AIN. Objective: To find out the effect of date palm extract ‘ajwa varieties to the amount of inflammatory cell infiltration on white male rat kidneys which induced by Cotrimoxazole. Method: The method in this research is experimental with post test only control group design. Using a simple random sampling technique. The experimental animal used was white male wistar rat aged 2 to 3 months with the total of 25 rats divided into 5 groups consists of negative control group, positive control group which induced by cotrimoxazole 36mg/200grBB/day, and the group which given date palm extract 7,5mg/day, 15mg/day and 30mg/day with induced by Cotrimoxazole 36mg/200grBB/day. Result: One Way Annova test found a significant effect between ‘ajwa date palm to the amount of inflammatory cell infiltration of white male eat kidneys which induced by cotrimoxazole (p<0,05). Proceed by Post Hoc Benferroni test found p<0,05 points in all groups which means there were significant difference between positive control group and each of treatment group. Conclusion: Date palm extract ‘ajwa varieties can prevent the increase in the amount of inflammatory cell infiltration on white male wistar rat which induced by cotrimoxazole. (*) Teaching staff Medical Faculty, University of Muhammadiyah Malang. (**) Teaching staff Medical Faculty University of Muhammadiyah Malang.