PENGARUH EKSTRAK ETANOL KUNCUP ROSELLA (HIBISCUS SABDARIFFA) TERHADAP GAMBARAN ENDAPAN KALSIUM OKSALAT PADA TUBULUS GINJAL PADA TIKUS PUTIH (RATTUS NOVERGICUS STRAIN WISTAR) JANTAN MODEL BATU GINJAL
Daftar Isi:
- Background: Ethylene glychol is a causative substance of nephrolithiasis. Hibiscus sabdariffa has several useful igredients such as anthocyanin and citric acid that inhibits the formation of calcium oxalate crystal. Objective: To find out the effect of roselle bud ethanol extract to the overview of calcium oxalate crystal on the kidney tubules of white rat kidney stone model. Methods: True experimental with post test control group design approaches. The sample is white male wistar rat which is divided into 5 group, positive control group, treatment group 1,2, and 3. True negative control group was only given food and drink, positive control group induced by EG and ammonium chloride during 28 days, treatment group 1,2 and 3 induced by EG and ammonium chloride and given roselle buds extract with multilevel dosages during 28 days. Result: One Way Annova test found a significant effect between roselle bud ethanol extract to the overview of calcium oxalate crystal on the kidney tubules of white rat (p<0,05). Proceed by Post Hoc Benferroni test found p<0,05 points in all groups which means there was significant effect between positive control group and each of treatment group. Conclusion: The administration of roselle buds extract has the effect of decreasing of calcium oxalate crystal on the kidney tubules of male white rat kidney stone model.