Effect of Extract Black Cumin (Nigela Sativa) on the LDL/HDL Ratio of Ovariectomized White Mouse (Rattus Novergicus Strain Wistas)
| Main Authors: | Andriana, Kusuma, Nelasari, Halida, Wiyasa, I Wayan Arsana |
|---|---|
| Format: | Article PeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
AENSI Publishing
, 2015
|
| Subjects: | |
| Online Access: |
http://eprints.umm.ac.id/57894/7/Andriana%20Nelasari%20Wiyasa%20-%20Black%20Cumin%20Extract%20Menopause%20LDL%20HDL%20LDLHDL%20Ratio.pdf http://eprints.umm.ac.id/57894/ http://www.aensiweb.net/AENSIWEB/aeb/aeb/2015/October/229-232.pdf |
Daftar Isi:
- Changes in fat metabolism by estrogen deficiency is one of the factors increasing the risk of CHD in postmenopausal women. Black cumin (Nigella sativa) is a spice that can be used as a medicinal plant. From several studies, Nigella sativa could show the effects of estrogen. Objective: to determine the effect of black cumin (Nigella sativa) against changes on LDL/HDL ratio of the ovariectomized white mouse (Rattus novergicus wistar strain) Method : True Experimental design with the post test only control group design with 25 female mouse divided into five groups : 2 controle group positive and negative, and 3 treatment groups of black cumin extract at a dose of 1.25, 2.5 and 5 mg/kg BW /day. Results : One way ANOVA test showed the non significant value (p > 0.05) of weight changes (p: 0.055), HDL level (p : 0.326) and LDL level ( p: 0.659). At Kruskal-Wallis test showed the non significant value of LDL/HDL ratio (p : 0.152 (p > 0.05)). Conclusion : Extract of black cumin (N. sativa) could not significant affect on LDL/HDL ratio of the ovariectomized white mouse (Rattus novergicus wistar strain)