pengaruh ekstrak jahe merah (Zingiber officinale Rosc.Var. Rubrum) terhadap kadar sitokin interleukin 1β pada tikus putih (Rattus norvegicus strain wistar) yang diinduksi dengan pirazinamid, etambutol dan levofloksasin
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56107 |
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<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><relation>http://eprints.umm.ac.id/56107/</relation><title>pengaruh ekstrak jahe merah (Zingiber officinale Rosc.Var. Rubrum) terhadap kadar sitokin interleukin 1β pada tikus putih (Rattus norvegicus strain wistar) yang diinduksi dengan pirazinamid, etambutol dan levofloksasin.</title><creator>kusuma, muhammad anfal agdias</creator><subject>L Education (General)</subject><subject>R Medicine (General)</subject><subject>RS Pharmacy and materia medica</subject><description>Background : Pyrazinamide, ethambutol, and levofloxacin are anti-tuberculous SLD which are mostly consumed by patients. These three drugs are of the type that might cause the most common side effect i.e. gastrointestinal disorders in the form of nausea (79.8%), and vomiting (78.9%). These effects can cause the patient to stop the medication (breaking up medication) which can cause resistance. the effects of SLD indicate an inflammatory response in the body that will respond to the immune system where IL-1β has a key role in the inflammatory process. Red ginger is known to have oleoresin which can function as the highest anti-inflammatory among other ginger variants.
Objective : To determine the effect of red ginger extract on the levels of interleukin 1β cytokines in white rats (Rattus norvegicus strains wistar) induced with pyrazinamide, levofloxacin, and ethambutol.
Methods : True experimental with posttest only control group design. The sample was divided into 5 groups (negative control, positive control, 100mg/KgBB, 200mg/KgBB, 400mg/KgBB). Levels of IL 1β were measured in blood serum using the ELISA method. Analyzed using One-Way ANOVA and Bonferroni Post-Hoc tests.
Results and Discussion : Based on the results of One-Way ANOVA and Post-Hoc Bonferroni the significant value of the interleukin 1β level was (0.00) which means that there was a significant difference in the interleukin 1β level. This is because the content of shogaol which is included on oleoresin in red ginger extract can prevent or reduce the production of IL 1β in a straightforward manner and it also inhibits NFκB.
Conclusion : There was a significant effect of the administration of red ginger extract on the decrease in the levels of interleukin 1β cytokines in the blood serum of male white rats induced by pyrazinamide, ethambutol, and levofloxacin.</description><date>2019-11-19</date><type>Thesis:Thesis</type><type>PeerReview:NonPeerReviewed</type><type>Book:Book</type><language>eng</language><identifier>http://eprints.umm.ac.id/56107/1/Pendahuluan.pdf</identifier><type>Book:Book</type><language>eng</language><identifier>http://eprints.umm.ac.id/56107/2/BAB%201.pdf</identifier><type>Book:Book</type><language>eng</language><identifier>http://eprints.umm.ac.id/56107/3/BAB%202.pdf</identifier><type>Book:Book</type><language>eng</language><identifier>http://eprints.umm.ac.id/56107/4/BAB%204.pdf</identifier><type>Book:Book</type><language>eng</language><identifier>http://eprints.umm.ac.id/56107/5/BAB%203.pdf</identifier><type>Book:Book</type><language>eng</language><identifier>http://eprints.umm.ac.id/56107/6/BAB%205.pdf</identifier><type>Book:Book</type><language>eng</language><identifier>http://eprints.umm.ac.id/56107/7/BAB%206.pdf</identifier><type>Book:Book</type><language>eng</language><identifier>http://eprints.umm.ac.id/56107/8/BAB%207.pdf</identifier><type>Book:Book</type><language>eng</language><identifier>http://eprints.umm.ac.id/56107/9/LAMPIRAN.pdf</identifier><identifier> kusuma, muhammad anfal agdias (2019) pengaruh ekstrak jahe merah (Zingiber officinale Rosc.Var. Rubrum) terhadap kadar sitokin interleukin 1β pada tikus putih (Rattus norvegicus strain wistar) yang diinduksi dengan pirazinamid, etambutol dan levofloksasin. Bachelors Degree (S1) thesis, University of Muhammadiyah Malang. </identifier><recordID>56107</recordID></dc>
|
| language |
eng |
| format |
Thesis:Thesis Thesis PeerReview:NonPeerReviewed PeerReview Book:Book Book |
| author |
kusuma, muhammad anfal agdias |
| title |
pengaruh ekstrak jahe merah (Zingiber officinale Rosc.Var. Rubrum) terhadap kadar sitokin interleukin 1β pada tikus putih (Rattus norvegicus strain wistar) yang diinduksi dengan pirazinamid, etambutol dan levofloksasin |
| publishDate |
2019 |
| topic |
L Education (General) R Medicine (General) RS Pharmacy and materia medica |
| url |
http://eprints.umm.ac.id/56107/1/Pendahuluan.pdf http://eprints.umm.ac.id/56107/2/BAB%201.pdf http://eprints.umm.ac.id/56107/3/BAB%202.pdf http://eprints.umm.ac.id/56107/4/BAB%204.pdf http://eprints.umm.ac.id/56107/5/BAB%203.pdf http://eprints.umm.ac.id/56107/6/BAB%205.pdf http://eprints.umm.ac.id/56107/7/BAB%206.pdf http://eprints.umm.ac.id/56107/8/BAB%207.pdf http://eprints.umm.ac.id/56107/9/LAMPIRAN.pdf http://eprints.umm.ac.id/56107/ |
| contents |
Background : Pyrazinamide, ethambutol, and levofloxacin are anti-tuberculous SLD which are mostly consumed by patients. These three drugs are of the type that might cause the most common side effect i.e. gastrointestinal disorders in the form of nausea (79.8%), and vomiting (78.9%). These effects can cause the patient to stop the medication (breaking up medication) which can cause resistance. the effects of SLD indicate an inflammatory response in the body that will respond to the immune system where IL-1β has a key role in the inflammatory process. Red ginger is known to have oleoresin which can function as the highest anti-inflammatory among other ginger variants.
Objective : To determine the effect of red ginger extract on the levels of interleukin 1β cytokines in white rats (Rattus norvegicus strains wistar) induced with pyrazinamide, levofloxacin, and ethambutol.
Methods : True experimental with posttest only control group design. The sample was divided into 5 groups (negative control, positive control, 100mg/KgBB, 200mg/KgBB, 400mg/KgBB). Levels of IL 1β were measured in blood serum using the ELISA method. Analyzed using One-Way ANOVA and Bonferroni Post-Hoc tests.
Results and Discussion : Based on the results of One-Way ANOVA and Post-Hoc Bonferroni the significant value of the interleukin 1β level was (0.00) which means that there was a significant difference in the interleukin 1β level. This is because the content of shogaol which is included on oleoresin in red ginger extract can prevent or reduce the production of IL 1β in a straightforward manner and it also inhibits NFκB.
Conclusion : There was a significant effect of the administration of red ginger extract on the decrease in the levels of interleukin 1β cytokines in the blood serum of male white rats induced by pyrazinamide, ethambutol, and levofloxacin. |
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IOS4109.56107 |
| institution |
Universitas Muhammadiyah Malang |
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136 |
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library:university library |
| library |
Perpustakaan Universitas Muhammadiyah Malang |
| library_id |
546 |
| collection |
UMM Institutional Repository |
| repository_id |
4109 |
| city |
MALANG |
| province |
JAWA TIMUR |
| repoId |
IOS4109 |
| first_indexed |
2019-11-23T23:30:09Z |
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2019-11-23T23:30:09Z |
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dc |
| _version_ |
1686087608569954304 |
| score |
17.538404 |