PENGARUH EKSTRAK DAUN KECAPI (SANDORICUM KOETJAPE) TERHADAP KADAR MALONDIALDEHID (MDA) PADA TIKUS PUTIH JANTAN (RATTUS NORVEGICUS) STRAIN WISTAR DISLIPIDEMIA
Daftar Isi:
- Background: Dyslipidemia is a lipid metabolic disorder which causes oxidative stress condition due to high free radical levels inside the body and triggers lipid peroxidation process to produce MDA. MDA is a mutagenic and tumorigenic that can affect atherosclerosis. Santol (Sandoricum koetjape) leaf contains flavonoid, saponin, triterpenoid, steroid, and phenolic as natural antioxidants which are expected to inhibit the increase of MDA levels due to free radical effects. Objectives: To determine the effect of Santol (Sandoricum koetjape) leaf extract on MDA levels of white male Wistar strain rats (Rattus norvegicus) with dyslipidemia. Methods: Experimental research with post test only control group design. Fifteen white male Wistar strain rats as samples were divided into five groups consist of one normal group, one control group (given used cooking oil), and three experimental groups (given used cooking oil+Santol leaf extract with the doses of 1,33; 2,66; 5,32 (mg/200grBW)). The measurement of blood MDA levels using TBARS method. Data was analyzed using ANOVA, Post Hoc, and Linear Regression test. Results and Discussions: ANOVA test results showed a significant effect (p: 0,006). Post Hoc test results showed significant difference (p<0,05) in 5,32mg/200grBW dose group. Linear regression test results showed that Santol leaf extract has an effect of 73,3% on decreasing blood MDA levels. It was due to flavonoid, saponin, triterpenoid, steroid, and phenolic in santol leaf that could inhibit free radical effects. Conclusion: Santol (Sandoricum koetjape) leaf extract decreases MDA levels in white male Wistar strain rats (Rattus norvegicus) with dyslipidemia.