PENGARUH EKSTRAK DAUN PEPAYA (Carica papaya L.) TERHADAP KADAR SGOT DAN SGPT SERUM DARAH TIKUS PUTIH JANTAN (Rattus novergicus strain wistar) YANG DIINDUKSI MSG (Momosodium Glutamate)
| Main Author: | Fitriyah, Atiqotul |
|---|---|
| Format: | Thesis NonPeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
, 2019
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| Subjects: | |
| Online Access: |
http://eprints.umm.ac.id/53583/1/PENDAHULUAN.pdf http://eprints.umm.ac.id/53583/2/BAB%201.pdf http://eprints.umm.ac.id/53583/3/BAB%202.pdf http://eprints.umm.ac.id/53583/4/BAB%203.pdf http://eprints.umm.ac.id/53583/5/BAB%204.pdf http://eprints.umm.ac.id/53583/6/BAB%205.pdf http://eprints.umm.ac.id/53583/7/BAB%206.pdf http://eprints.umm.ac.id/53583/8/BAB%207.pdf http://eprints.umm.ac.id/53583/9/LAMPIRAN.pdf http://eprints.umm.ac.id/53583/ |
Daftar Isi:
- Background: Liver has an important role for the body and the prevalence of liver disease is still increasing. Hepatocellular injury marked by increased SGOT and SGPT serum. Papaya leaves contain antioxidant compounds, namely phenolic, flavonoids, alkaloids, saponins, vitamin C and vitamin E which expected can attenuate hepatocellular injury by inhibiting oxidative stress due to the accumulation of free radicals caused by MSG. Objective: To determine the effect of papaya leaves extract (Carica papaya L.) on SGOT and SGPT levels of male white rat induced by MSG. Method: True Experiment with post test only control group design. 16 rats as samples were divided into 4 groups, the positive control group (induced by MSG) 3 treatment groups (induced by MSG, and papaya young leaves extract 30, 60, and 120 [mg / 200 grWB / day]). SGOT and SGPT levels were measured by spectrophotometer with wavelength of 340 nm. The data were analyzed using Manova test and Post Hoc Bonferroni test. Results and Discussion: Manova test results showed that the difference of SGOT and SGPT levels of rats were significant (p=0.000) and (p=0.000) among groups. Post Hoc test results obtained a dose of 30 mg/200 grWB/ day has begun to show a significant decrease of SGOT and SGPT levels and a dose 120 mg/200 grWB/day show the lowest to be in the normal range. This was occured because the content of antioxidant compounds were phenolic, flavonoids, alkaloids, saponins, vitamin C and vitamin E in papaya leaves. Conclusion: Papaya leaves extract (Carica papaya L.) has effect prevent uppering SGOT and SGPT levels on blood serum of white male rats (Rattus novergicus strain wistar) induced by MSG.