STUDI PENGGUNAAN OBAT GOLONGAN ANGIOTENSIN CONVERTING ENZYME INHIBITORS (ACE-I) PADA PASIEN SINDROM NEFROTIK (Penelitian dilakukan di RSUD Dr. Saiful Anwar Malang)
Daftar Isi:
- Background : Nephrotic Syndrome (NS) is a clinical syndrome defined as proteinuria >3,5 g/day in adults and 40 mg/m2/hour in children which associated with hypoalbuminemia, edema, and hyperlipidemia. ACE-I as supportive proteinuria therapy by influencing renal hemodynamics leads to decrease intraglomerular pressure and acting as renoprotector by controlling the increase of proinflammatory cytokines and glomerular cell component remodeling. Objective : This study aims to determine the use of angiotensin converting enzyme inhibitors (ACE-I) in NS patients at Dr. Saiful Anwar General Hospital of Malang from period January to December 2018. Method : Retrospective observational in NS patient at Dr. Saiful Anwar General Hospital of Malang from period January to December 2018. Results and Conclusion : The pattern of single use of ACE-I was 8 patients (7%), combination 2 was 42 patients (35%), combination 3 was 61 patients (53%) and combination 4 was 7 patients (6%). The highest single use was Captopril (3 x 6.25 mg) po in 3 patients (38%). The most common used of combination 2 wereACE-I + Corticosteroids in 34 patients (80%). Combination 3 were ACE-I + ARB + Corticosteroids in 43 patients (70%). The use of combination 4 has 1 pattern, it was ACE-I + ARB + Corticosteroid + Immunosuppressant in 7 patients (100%). The pattern of switching therapy has 35 patterns.