Potensi Ekstrak Kelopak Rosella (Hibiscus sabdariffa linn) Dalam Mencegah Aterosklerosis
| Main Author: | Afrians, Keky |
|---|---|
| Format: | Thesis NonPeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
, 2019
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| Subjects: | |
| Online Access: |
http://eprints.umm.ac.id/48378/1/Pendahuluan.pdf http://eprints.umm.ac.id/48378/2/BAB%20I.pdf http://eprints.umm.ac.id/48378/3/BAB%20II.pdf http://eprints.umm.ac.id/48378/4/BAB%20III.pdf http://eprints.umm.ac.id/48378/5/BAB%20IV.pdf http://eprints.umm.ac.id/48378/6/lampiran.pdf http://eprints.umm.ac.id/48378/ |
Daftar Isi:
- Atherosclerosis is a condition in which there is a build-up of lipids in the lumen of the coronary artery so that it progressively narrows the lumen of the artery and can reduce the ability of blood vessels to dilate. Atherosclerosis begins with the process of changing LDL-cholesterol which experiences oxidation to oxidized LDL (Ox LDL). Then it will be more risky if the blood vessels are likely to decrease the secretion of nitric oxide (NO) produced by endothelial cells. NO itself serves to protect blood vessel endothelial walls from materials that are at risk of sticking and forming thrombus such as Ox LDL, platelets and monocytes that turn into macrophages. Ox LDL can be directly inhibited by antioxidants by inhibiting its free radicals. Excessive free radicals sometimes cannot be lowered by antioxidants in the body alone which require the help of antioxidants from the outside. A natural source of external antioxidants comes from plants, one of which itself is rosella sheath. Roselle sheath are medicinal plants that contain compounds of flavonoids, alkaloids, saponins, and tannins. Flavonoids themselves can be used as antithrombotic and vasodilator effects. Rosella sheath extract has the potential to prevent atherosclerosis. Keyword: Rosella sheath extract, atherosclerosis (*) Lecturer of Patholgy Anatomi, Medical Faculty University of Muhammadiyah Malang (**) Lecturer of Pharmacology, Medical Faculty University of Muhammadiyah Malang