PREDIKSI AKTIVITAS SENYAWA METABOLIT SEKUNDER RIMPANG Homalomena occulta SEBAGAI DNA GYRASE INHIBITOR SECARA IN SILICO
Daftar Isi:
- Infection on urinary tract is bacterial infection that is caused by the growth of microorganism in urinary tract of human. Infection of urinary tract caused several complications such as urinary tract stone, urinary tract obstruction, sepsis, multidimensional bacterial infection and others kidney disorders. Society of Indonesia, especially Madiun society used Nampu rhizome as medicine for kidney stone. This study purposed to predict metabolite compounds on plant of Homalomena occulta that provided activity of DNA Gyrase Inhibitor pharmacodynamics and pharmacokinetics. This study used software of Autodock for pharmacodynamics test and web SwissADME to observe the profile of pharmacokinetics. According to the analysis result could be concluded that there were 85 compounds on Homalomena occulta that tested and obtained 7 compounds that predicted has DNA activity of Gyrase Inhibitor. There were 5 predicted compounds that had high absorption of GI and suspected to had good profile of pharmacokinetics.