Pengaruh Ekstrak Buah Mengkudu (Morinda Citrifolia) Terhadap Diameter Sel Langerhans Tikus Putih (Rattus Novergicus Strain Wistar) Yang Di Induksi Streptozotocin
Daftar Isi:
- Jannah, Anina Ni’matul. 2019, Effect of Noni Fruit Extract (Morinda citrifolia) on Langerhans Cell Diameter of White Rat (Rattus novergicus strain wistar) induced by Streptozotocin. Final Assignment of Medical Faculty of Muhammadiyah Malang University. Advisors : (I) dr. Dian Yuliarta Lestari, Sp.PA (II) dr. Gita Sekar Prihanti, M.Pd.Ked Background: Hyperglycemia accelerate the increasing of ROS production and cause many pancreatic cells damage inducing oxydative stress and reduce the diameter of langerhans’ cell. Noni fruit has a hypoglycemic effect and antioxidant activity which is able to regenerate beta cells damage and followed by increasing the diameter of Langerhans’ cells Objective: To determine the effect of noni fruit extract (Morinda citrifolia) on Langerhans cell’s diameter of white rat (Rattus novergicus strain wistar) induced by streptozotocin Method: True Experiment with Post test-only control group design. 16 rats as a sample were divided into 4 groups: control group (STZ 60 mg/kgBW), Extract with dose of 50, 100, 200 mg/kgBW for 25 days. Measurement of Langerhans cell diameter using Image Raster software 3. The data were analyzed by using test One-Way ANOVA, Post Hoc Bonferroni test and regression test. Result and Discussion: One-Way ANOVA results showed the data of all treatment groups were significant (P<0.05). This experiment showed that 50mg/KgBW was the dose that starts for give an effect to Langerhans’ diameter. Regression test results indicated that Noni fruit’s extract had an effect of 62.5% on Langerhans’ cell diameter (R2=0.625). This was probably due to antioxidant compounds such as flavonoids and alkaloids at noni fruit Conclusion: Noni fruit’s extract shows a significant effect on the diameter of Langerhans’ cell white rat Keyword: Hyperglycemia, Diameter of Langerhans’ Cell, Pancreas, Noni fruit