PENGARUH EKSTRAK MENIRAN (Phyllanthus niruri L.) TERHADAP KADAR HB DAN PCV DARAH TIKUS PUTIH JANTAN (Rattus novergicus strain wistar) YANG DIPAPAR TIMBAL ASETAT
Daftar Isi:
- Background: Exposure of lead acetate causes erythrocyte damage marked by decreased Hb and PCV. Meniran (Phyllanthus niruri L) contain antioxidant compounds, tannin, vitamin C, phenolic, terpen, flavonoid and lignan which expected can attenuate erythrocyte damage by inhibiting oxidative stress due to the accumulation of free radicals caused by lead acetate. Objective: To determine the effect of meniran extract (Phyllanthus niruri L) increase Hb and PCV levels of male white rat induced by lead acetate. Method: True Experiment with post test only control group design. 16 rats as a sample were divided into 4 groups, the positive control group (induced by lead acetate) 3 treatment groups (induced by lead acetate, and meniran extract (Phyllanthus niruri L) 0,1, 0,2, and 0,4 [mg/grBW/day]). Hb and PCV levels are measured by Automated Hematology Analyser (Micros 6). The data were analyzed using test MANOVA, Post Hoc Bonferroni test and regression test. Results and Discussion: Results showed significant (p=0.001) effect of meniran extract and Hb and PCV levels. Post hoc test results obtained a dose of 0,2 mg/grBW/ day has begun to show a significant increase of Hb and PCV levels . The result of regression test showed 80,9% main effect of meniran extract for Hb and 61,1% for PCV levels on blood of white male rats (Rattus norvegicus) strain wistar. This is because antioxidant compounds, tannin, vitamin C, phenolic, terpen, flavonoid and lignan at meniran. Conclusion: Meniran extract (Phyllanthus niruri L) has effect increasing Hb and PCV levels on blood of white male rats (Rattus norvegicus) strain wistar induced by lead acetate.