PENGARUH PEMBERIAN KOMBINASI EKSTRAK ETANOL DAUN Persea americana DAN Annona squammosa TERHADAP KADAR TRIGLISIRIDA TIKUS Rattus novergieus HIPERLIPIDEMIA
Daftar Isi:
- Background : Coronary Heart Disease ( CHD ) is currently the leading cause of death in Indonesia. One cause of CHD is hyperlipidemia which increases the risk of CHD mortality due to atherosclerosis. Combination therapy of P. americana and A.squamosa synergistically can be an alternative therapy for hyperlipidemia. P. americana and A. squamosa contain quercetin that have a ability to inhibit LDL oxidation in order to balance RCT and increase HDL. Enhance of Triglisirida can prevent hyperlipidemia. Aim : To know the effect of ethanol extract from P. americana and A. squamosa on HDL levels in Rattus norvegicus. Method : This study used a true experimental and post test only control group design, there are six treatment groups with each group consisting of four male rats Rattus norvegicus. P1 dose group was given P. americana ( PA ) : A. squamosa (AS ) 125 mg / KgBW : 125 mg / KgBW, P2 group was given a dose of PA : AS 125 mg / KgBW : 250 mg / KgBW , P3 group was given a dose of PA : AS 250mg / KgBW : 125 mg / KgBW for 21 days, while the positive control group was given 0,018 mg simvastatin / 200gBB for 21 days, the negative control group receive the carrier solution of 0.5% CMC-Na for 21 days, the group of healthy animals were given a drink and standard feed ad libitum during the research period. Blood samples were taken after treatment and analyzed by direct methods homogenous assay. Result : There was no effect of dosing a combination of P. Americana ethanol extract and Anonna squamosa ethanol extract on the reduction of cholesterol levels in rats, After homogeneity testing, then one way ANOVA test was continued. One way ANOVA test results show a significance value of 0.894 where the value is more than 0.05 (p> 0.05). These results indicate that there were no significant differences.